Wellbutrin (Bupropion Hydrochloride)

Wellbutrin (bupropion hydrochloride) comes in two forms: sustained release (SR) and extended release (XL). It’s a norepinephrine and dopamine reuptake inhibitor.

It’s a common antidepressant and helps people feel better. But it can also cause side effects, some of which are mild and go away as you take the drug.


Wellbutrin is used to treat depression and seasonal affective disorder (SAD). It belongs to a class of antidepressants called norepinephrine and dopamine reuptake inhibitors.

It works by increasing the levels of brain chemicals norepinephrine and dopamine, which are thought to regulate mood. It’s often the first-line treatment for mild to moderate depression and SAD.

You’ll take this medication by mouth, usually once a day in the morning. It’s important to take it regularly, as it takes several weeks for the full effect of this medicine to take place.

Some side effects may go away within a week or two of starting this medicine, as your body adjusts to it. However, if you have more severe or bothersome symptoms, talk with your doctor.

People with bipolar disorder or risk factors for bipolar disorder (like family history) are at higher risk of manic episodes while taking this medication. It’s important to watch for signs and symptoms of a manic episode, including feeling excited, having high energy levels, or trouble sleeping.


Typically, you start by taking a low dose. Your doctor will adjust it over time to reach a dosage that is right for you.

Taking Wellbutrin daily helps prevent depression and reduces its symptoms. It is also used to treat seasonal affective disorder (SAD).

Bupropion belongs to a class of drugs called antidepressants. It works by inhibiting the reuptake of dopamine and norepinephrine in nerves. These chemicals are thought to be responsible for many symptoms of depression.

When taken correctly, Wellbutrin SR and Wellbutrin XL help people get better. They’re also used to prevent SAD, which is an episode of depression that happens in the fall and winter.

You can take the regular tablet (Wellbutrin SR) or an extended-release tablet (Wellbutrin XL). Both are long-acting and release their active drug slowly into your body over time.

Side effects

Wellbutrin is an antidepressant that’s used to treat major depressive disorder and seasonal affective disorder (SAD). It is also used off-label for a number of other conditions.

It may cause side effects, including restlessness, agitation, dizziness, and sweating. These symptoms usually go away after you take the medicine for a while.

If you experience agitation, anxiety, or mood changes, talk with your doctor. These can be signs of a more serious side effect, such as suicidal thoughts or behavior.

It’s important to tell your doctor if you have any of these feelings, because it can help them determine whether the problem is from Wellbutrin or from depression. It may also help you get the best treatment for your condition.


You should take Wellbutrin only as directed by your doctor. You can’t split or crush it, and you should never skip a dose.

Taking this drug with other medications can cause interactions and increase the risk of serious side effects. Talk to your doctor about all the drugs you’re taking, including over-the-counter medicines and supplements.

Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

People with narrow eye angles should not take Wellbutrin, as it can lead to closed-angle glaucoma (a medical emergency that can cause severe vision loss).

Seizures warning: This drug may increase the risk of seizures. Call your doctor right away if you have sudden or severe seizures.

You should also tell your doctor if you have a history of head injury, CNS infection, or severe stroke. You should also watch for suicidal thoughts or behaviors as you start using Wellbutrin.

Your doctor can prescribe other antidepressants that are safer for you to use. They may be called tricyclic antidepressants or SSRIs.